Background:  FKBP38 (FK506-binding protein 38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBP38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.

Description: Rabbit polyclonal to FKBP38

Immunogen: KLH conjugated synthetic peptide derived from FKBP38

Specificity:  ·Reacts with Human, Mouse, Dog, Cow, Chicken and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/500-1000. Predicted Mol wt: 45 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.